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Leaching of tobramycin from PMMA bone cement beads

✍ Scribed by von Frauhofer, J. A. ;Polk, H. C. ;Seligson, D.

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 291 KB
Volume: 19
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820190703

No coin nor oath required. For personal study only.

✦ Synopsis

The in vitro leaching characteristics of tobramycin from acrylic resin (PMMA) bone cement beads have been determined by a radioimmune assay. Tobramycin was incorporated at two concentrations into bone cement beads fabricated from three commercial brands of acrylic resin. Antibiotic leaching followed a curvilinear relation-shipoftheformX.Y = A . X + B . Y . A l l beads showed similar tobramycin leaching rates over time but the initial amount of leached material differed with the amount of tobramycin incorporated in the bead and the source of the PMMA bone cement. The data indicate that tobramycin-impregnated PMMA beads permit antibiotic leaching at a controlled rate compatible with possible clinical application.

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