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LDK378: A Promising Anaplastic Lymphoma Kinase (ALK) Inhibitor

✍ Scribed by Chen, Jianyong; Jiang, Cheng; Wang, Shaomeng

Book ID
120528768
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
215 KB
Volume
56
Category
Article
ISSN
0022-2623

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## Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic fusion formsβ€”the most common being nucleophosmin (NPM)‐ALKβ€”in a non‐Hodgkin's lymphoma (N