We have previously detected a single base substitution of G by A at the Arg codon CGC in exon 4 of the mutant lactate dehydrogenase (LDH) gene, an unstable LDH-B variant (case 1). Here, we use the polymerase chain reaction (PCR) to amplify genomic DNA of two cases (the original case 1 and a new pati
LDH calcutta-1: A mutation of the B subunit of human lactate dehydrogenase
β Scribed by A. E. C. Cutten
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 454 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0006-2928
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A new electrophoretic variant of the lactate dehydrogenase B subunit was found in the erythrocytes of the COP strain of the rat. The location of the band after the electrophoresis suggested a product of the structural gene for the B subunit. Two alleles that regulated the high amount (Ldh-2a) or the