✦ LIBER ✦
LDA-Mediated Cascade Carbolithiation Reactions of Vinylidenecyclopropanes with Enones and N-Sulfonated Imines as well as Nitroalkene and (Phenylmethylidene)malononitrile
✍ Scribed by Bei-Li Lu; Jian-Mei Lu; Min Shi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 710 KB
- Volume
- 2012
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Abstract
LDA‐mediated cascade carbolithiation reactions of vinylidenecyclopropanes with enones and N‐sulfonated imines as well as nitroalkene and (phenylmethylidene)malononitrile in THF at –78 °C have been realized; the corresponding novel adducts were produced in moderate to good yields with moderate to high diastereoselectivities. The scope and limitations are discussed as well as a plausible reaction mechanism based on control experiments performed in this work and previous literature reports.