A sensitive RIA was used to examine regulation of IGFBP-1 in H411E rat hepatoma cells. IGFBP-1 was stimulated up to tenfold by dexamethasone and corticosterone, and this stimulation was abolished by RU486. The effect of dexamethasone increased with time in culture. Phorbol 12-myristate 13-acetate (P
Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor
✍ Scribed by Joanna S Brooke; Jeong-Heon Cha; Leon Eidels
- Publisher
- BioMed Central
- Year
- 2002
- Tongue
- English
- Weight
- 338 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1471-2121
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## Abstract Insulin‐like growth factor 1 (IGF‐1) and its major binding protein, IGF binding protein 3 (IGFBP‐3) are implicated in lung cancer and other malignancies. We have previously shown that the combination of three major antioxidants [β‐carotene (BC), α‐tocopherol (AT) and ascorbic acid (AA)]