Latent and lytic Epstein-Barr virus gene expression in the peripheral blood of astronauts

✍ Scribed by Raymond P. Stowe; Elena V. Kozlova; Clarence F. Sams; Duane L. Pierson; Dennis M. Walling

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 78 KB
• Volume: 83
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.22079

✦ Synopsis

Abstract

Epstein‐Barr virus (EBV) latent and replicative gene transcription was analyzed in peripheral blood B‐lymphocytes from astronauts who flew on short‐duration (∼11 days) Shuttle missions and long‐duration (∼180 days) International Space Station (ISS) missions. Latent, immediate‐early, and early gene replicative viral transcripts were detected in samples from six astronauts who flew on short‐duration Shuttle missions, whereas viral gene transcription was mostly absent in samples from 24 healthy donors. Samples from six astronauts who flew on long‐duration ISS missions were characterized by expanded expression of latent, immediate‐early, and early gene transcripts and new onset expression of late replicative transcription upon return to Earth. These data indicate that EBV‐infected cells are no longer expressing the restricted set of viral genes that characterize latency but are expressing latent and lytic gene transcripts. These data also suggest the possibility of EBV‐related complications in future long‐duration missions, in particular interplanetary travel. J. Med. Virol. 83:1071–1077, 2011. © 2011 Wiley‐Liss, Inc.