𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Late onset Wilson's disease: Therapeutic implications

✍ Scribed by Anna Członkowska; Maria Rodo; Grażyna Gromadzka

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
57 KB
Volume
23
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The clinical symptoms of Wilson's disease (WD) usually develop between 3 and 40 years of age and include signs of liver and/or neurologic and psychiatric disease. We report on an 84‐year‐old woman with WD. Despite the absence of treatment, the only symptom she presented with, until the age of 74 years, was Kayser‐Fleisher rings. At the age of 74, she developed slightly abnormal liver function. This case raises the following issues: (a) Should WD be considered in all patients of all ages who manifest signs related to the disease? (b) Are ATP7B mutations fully penetrant? (c) Should all patients diagnosed presymptomatically receive anticopper therapy? © 2008 Movement Disorder Society

📜 SIMILAR VOLUMES

Clinical course of late-onset Crohn's di
Clinical course of late-onset Crohn's disease
✍ Erika Angelucci; Andrea Cocco; Giovanni Latella; Renzo Caprilli 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 1 views
Retinoid receptors, transporters, and me
Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease
✍ Ann B. Goodman 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 1 views

## Abstract Vitamin A (retinoid) is required in the adult brain to enable cognition, learning, and memory. While brain levels of retinoid diminish over the course of normal ageing, retinoid deficit is greater in late onset Alzheimer disease (LOAD) brains than in normal‐aged controls. This paper rev

McArdle's disease presenting with asymme
McArdle's disease presenting with asymmetric, late-onset arm weakness
✍ Gil I. Wolfe; Noel S. Baker; Ronald G. Haller; Dennis K. Burns; Richard J. Baroh 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB 👁 1 views

McArdle's disease or myophosphorylase deficiency is one of the most common muscle glycogenoses and typically presents in childhood or adolescence with exercise intolerance, myalgia, myoglobinuria, and cramps in exercising muscle. We describe an elderly man who developed asymmetric proximal arm weakn

Tarsal arthritis with ankylosis in late
Tarsal arthritis with ankylosis in late onset still's disease
✍ L. A. Healey; Robert F. Willkens 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 2 views

Medsger and Christy have described the roentgenographic pattern of carpometacarpal or intercarpal ankylosis that is distinctive of the systemic-onset (Still's-type) variant of juvenile rheumatoid arthtitis, particularly with adult onset (1). We report here 2 patients with an illness consistent with

Familial aggregation of early- and late-
Familial aggregation of early- and late-onset Parkinson's disease
✍ Karen Marder; Gilberto Levy; Elan D. Louis; Helen Mejia-Santana; Lucien Cote; Ho 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 2 views

The role of heredity in early- versus late-onset Parkinson's disease (PD) is controversial. We estimated the degree of increased risk of PD in first-degree relatives of 221 PD probands with age of onset 50 years or younger and 266 PD probands with age of onset older than 50 years compared with the f