Late onset aplastic anemia during treatment of chronic myeloid leukemia with imatinib mesylate
β Scribed by G. LeMarbre; C. Schinstock; R. Hoyer; J. Krook; A. Tefferi
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 61 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0145-2126
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π SIMILAR VOLUMES
The BCR/ABL tyrosine kinase inhibitor imatinib mesylate produces a high rate of cytogenetic responses in patients with Philadelphia (Ph)-positive chronic myeloid leukemia (CML), but secondary clonal chromosome abnormalities may develop in Ph-negative cells, and acute myeloid leukemia (AML) has been
## Abstract ## BACKGROUND Myelosuppression occurs in up to 50% of patients with chronic myeloid leukemia (CML) who are treated with imatinib and β₯ Grade 3 myelosuppression is reported in approximately 10% of patients. ## METHODS The authors investigated the prognostic significance of anemia occu