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Late esophageal toxicity after radiation therapy for head and neck cancer

✍ Scribed by Allen M. Chen; Bao-Qing Li; Richard L. S. Jennelle; Derick H. Lau; Claus C. Yang; Jean Courquin; Srinivasan Vijayakumar; James A. Purdy

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
89 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

The aim of this study was to determine the incidence of esophageal toxicity after radiation therapy for head and neck cancer.

Methods.

The records of 211 patients treated by radiation therapy for head and neck cancer were reviewed to identify those with dysphagia lasting more than 90 days after therapy. Late toxicity criteria established by the Radiation Therapy Oncology Group were used to score the symptoms.

Results.

The incidence of grade 3+ esophageal toxicity at 3 and 6 months was 30% and 19%, respectively. The rate of gastrotomy‐tube dependence at 3 and 6 months was 20% and 11%, respectively. Hypopharyngeal and unknown primary site (p = .01, for both), T4 disease (p = .01), and the use of concurrent chemotherapy (p = .001) were associated with grade 3+ esophageal toxicity and stricture formation.

Conclusion.

A significant proportion of patients exhibit symptoms of esophageal toxicity after radiation therapy for head and neck cancer. Therefore, preventive strategies need further investigation. Β© 2009 Wiley Periodicals, Inc. Head Neck, 2010

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