Late components of the event-related potentials and their topography in Parkinson's disease

✍ Scribed by Dr. Jim Lagopoulos; Paul Clouston; Homayoun Barhamali; Evian Gordon; Waiman M. Li; Julian Lesley; John G. L. Morris

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 626 KB
• Volume: 13
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870130211

✦ Synopsis

Abstract

Late components of the event‐related potential (ERP; N100, P200, N200, and P300) were elicited using an auditory oddball paradigm (with a button‐press response to target stimuli) in 15 Parkinson's disease (PD) patients and 50 normal control subjects. Compared with control subjects, PD subjects showed a significant decrease in N200 amplitude. Between‐group topographical differences in N200 amplitude were evident at central (C3, Cz, C4) and temporal (T5, T3, T4, T6) regions. The results may reflect a deficit in response selection in PD possibly resulting from a dysfunction associated with the abnormalities in the central and temporal regions found to have a decreased N200 amplitude compared with normal control subjects in this study.