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Cover micrograph: Histological sections from acute biopsies (regressive H&E stain). The scale of these photographs is indicated by the 100-m bar in (a) (original magnification: 100Γ). a: Non-irradiated skin (control). b: Deep collagen coagulation ($270 m; see the arrow), obtained with a sequence of ten 550-m pulses (single-pulse fluence F ΒΌ 1.6 J/cm 2 , repetition rate v ΒΌ 20 Hz) and no CSC. c: At a higher fluence (F ΒΌ 4.3 J/cm 2 ), the epidermis is completely ablated, and the coagulation depth is diminished (to $210 m; arrow) d: With 6-ms CSC spurts applied just prior to and during each laser pulse, the epidermis is preserved even at a relatively high fluence (F ΒΌ 3.4 J/cm 2 ). The coagulation layer is less thick, but still considerable (arrow). See accompanying article by Majaron et al., on pages 121-130 in this issue.
π SIMILAR VOLUMES
Cover micrograph: Region of interest selected for LSI. The region was selected to include both PWS and normal skin. SFI maps (C,D) of a selected skin area treated with a pulsed dye laser. Parts (A,B) are gray scale images. Images were acquired (A,C) immediately before and (B,D) 15 minutes after trea