Laserinduced thermotherapy (LITT) of experimental livermetastasis—detection of residual tumors using Gd-DTPA enhanced MRI
✍ Scribed by Christoph Isbert; Jörg-P. Ritz; Andreas Schilling; André Roggan; Antje Heiniche; Karl-J. Wolf; Gerhard Müller; Heinz J. Buhr; Christoph-T. Germer
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 243 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Abstract
Background and Objective
The aim of this study was to evaluate the accuracy of Gd‐DTPA MRI in the detection of recurrent tumor after laserinduced thermotherapy (LITT) of experimental liver metastases.
Study Design/Materials and Methods
LITT was performed at different energy levels in VX‐2 tumor‐bearing rabbits (n = 80). MRI and histology were placed at 0, 24, 96 hours, and 14 days. Signal intensities were calculated of the transition between thermally damaged and undamaged tissue (transition zone = TZ) and of the surrounding tissue (reference zone = RZ).
Results
Tumor recurrence was seen in 47 animals. At 24 hours sensitivity, specificity and accuracy was 92, 100, and 95% in TZ and 23, 100, and 50% in RZ. At 14 days sensitivity, specificity and accuracy was 100, 11, and 60% in TZ and 100, 89, and 95% in RZ.
Conclusions
Recurrence is best excluded in TZ at 24 hour and in RZ at 14 day with an accuracy up to 95%. Lasers Surg. Med. 30:280–289, 2002. © 2002 Wiley‐Liss, Inc.