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✦   LIBER   ✦

Laser light scattering study of the degradation of poly(sebacic anhydride) nanoparticles

✍ Scribed by Jie Fu; Chi Wu

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
160 KB
Volume
39
Category
Article
ISSN
0887-6266

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✦ Synopsis

Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.

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