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Laser-induced carotid artery injury model in the rat for therapeutic agent screening

✍ Scribed by Chin-Hsien Chang; Kuo-Ti Chen; Chang-Jer Wu; Shih-Liang Chang; Ya-Huang Chiu; Pei-Hsiu Hung; Jih-Chao Yeh; Yen-Lin Chang

Book ID
113057092
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
320 KB
Volume
27
Category
Article
ISSN
0268-8921

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We report a new model of embolic stroke in the rat, based on endothelial disruption and platelet aggregation in the carotid artery, which leads to distal embolization and focal brain infarction. The common carotid artery was irradiated for 6.5 minutes with the focused beam of an argon laser operated