Laser Ablation Ion Trap Mass Spectrometry—Storage Field Suppression and its Effect Upon Analytical Performance
✍ Scribed by C. G. Gill; A. W. Garrett; N. S. Nogar; P. H. Hemberger
- Book ID
- 101237864
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 167 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-4198
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✦ Synopsis
The combination of laser desorption and ablation with mass spectrometry has been, and will continue to be, a useful marriage of technologies. Quadrupole ion trap mass spectrometry, which has evolved from a simple mass selective detector for gas chromatography to a high performance analytical tool over the last decade, is being coupled more frequently with desorption sources, such as lasers and particle beams. The present work addresses a shortcoming of the use of laser sampling with quadrupole ion traps: laser ablation of samples directly within the storage volume of the trap can lead to suppression of the RF storage field, thereby reducing ion-trapping efficiency during the ionization event. A systematic examination of the phenomenon has been conducted and the advantages of selective injection or ionization methods, such as resonant laser ablation, for elimination of this problem are presented.