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Large scale production and downstream processing of a recombinant porcine parvovirus vaccine

✍ Scribed by L. Maranga; P. Rueda; A. Antonis; C. Vela; J. Langeveld; J. Casal; M. Carrondo


Publisher
Springer
Year
2002
Tongue
English
Weight
79 KB
Volume
59
Category
Article
ISSN
1432-0614

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## Abstract ## Background One of the major limitations to the use of adeno‐associated virus (AAV) vectors for gene therapy has been the difficulty in producing enough vector to supply a clinical trial. More than 20 000 roller bottles may be required to generate AAV by the traditional transient tra