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Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies

✍ Scribed by Ösapay, George; Prokai, Laszlo; Kim, Ho-Seung; Medzihradszky, Katalin F.; Coy, David H.; Liapakis, George; Reisine, Terry; Melacini, Giuseppe; Zhu, Qin; Wang, Susan H.-H.; Mattern, Ralph-Heiko; Goodman, Murray

Book ID
127332459
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
441 KB
Volume
40
Category
Article
ISSN
0022-2623

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Synthesis and physicochemical characteri
Synthesis and physicochemical characterization of the lanthionine analog of somatostatin[1–14]
✍ George Ösapay; Giuseppe Melacini; Qin Zhu; Lida Tehrani; Murray Goodman 📂 Article 📅 1994 🏛 Springer Netherlands 🌐 English ⚖ 426 KB

The synthesis of the lanthionine analog of somatostatin[1-14] on a Kaiser-oxime resin is described. The 12residue peptide segment [3][4][5][6][7][8][9][10][11][12][13][14] was assembled and cyclized on the resin by using the method of peptide cyclization on an oxime resin (PCOR); the product was obt