Lanthanide triflate-catalyzed 1,3-dipolar cycloaddition reactions of polymer-supported nitrones with alkenes for the preparation of diverse 2-isoxazoline derivatives
✍ Scribed by Shū Kobayashi; Ryo Akiyama
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 248 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
1,3-Dipolar cycloaddition reactions of polymer-supported nitrones with alkenes proceeded smoothly in the presence of a catalytic amount of a lanthanide triflate to afford the corresponding 2-isoxazolines in high yields. Diverse 2-isoxazoline derivatives were prepared based on these solid-phase reactions.
📜 SIMILAR VOLUMES
The 1,3-dipolar cycloaddition reaction of homoadamantane-incorporated nitrones, 4-azahomoadamant-4-ene N-oxide (1) and 5-methyl-4-azahomoadamant-4-ene N-oxide (2), with various alkenes afforded 2-aza-3-oxatetracyclo[7.3.1.1711.0z6]tetradecane derivatives as the 1:1 cycloadduct. The reaction showed r