LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens

Primary human mesothelioma cells express

Primary human mesothelioma cells express class II MHC, ICAM-1 and B7–2 and can present recall antigens to autologous blood lymphocytes

✍ Luciano Mutti; Maria T. Valle; Bruno Balbi; Anna M. Orengo; Antonio Lazzaro; Pao 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 322 KB

Mesothelioma cells (MMc) are considered to be weakly immunogenic and the experimental approaches attempting to induce an immune response against these cells have been disappointing. Our aim was to investigate whether MMc possess the surface accessory molecules involved in antigen presentation and wh