Lamivudine vs lamivudine and interferon combination treatment of HBeAg(−) chronic hepatitis B
✍ Scribed by C. Yurdaydin; H. Bozkaya; H. Çetinkaya; T. Şahin; D. Karaoğuz; M. Törüner; Ö. Erkan; A. O. Heper; E. Erden; A. M. Bozdayi; Ö. Uzunalimoğlu
- Book ID
- 108885740
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 84 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1352-0504
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## Abstract The aim of this study was to elucidate the long‐term outcome after interferon (IFN) or lamivudine (LMV) treatment in Japanese patients with hepatitis B e antigen (HBeAg) positive chronic hepatitis B. Inclusion criteria were biopsy proven chronic hepatitis or liver cirrhosis, no history
## Abstract Hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7–30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia.
We have previously demonstrated that combination peginterferon and lamivudine treatment has superior antiviral efficacy to lamivudine monotherapy in chronic hepatitis B. In this study, we investigated the long-term posttreatment virological response to this combination treatment. Sustained virologic