Hepatitis B virus (HBV) reactivation has been described in cancer patients who received cytotoxic/immunosuppressive therapy and may result in liver damage of varying degrees of severity. There is no known effective treatment. Lamivudine, a nucleoside analogue, has been found to suppress HBV replicat
Lamivudine for hepatitis B in clinical practice
โ Scribed by Eugene R. Schiff
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 169 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0146-6615
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## Abstract A 53โyearโold man who had a history of fluminant hepatitis caused by precore mutant hepatitis B virus (HBV) was admitted to our hospital for the treatment of relapsed nonโHodgkin's lymphoma in July 2000. At admission, serum levels of aspartate aminotransferase and alanine aminotransfera
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Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the