Laminin-5-enriched extracellular matrix accelerates angiogenesis and neovascularization in association with ePTFE

SPARC expression is associated with impa

SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix

✍ Alexandre Chlenski; Shuqing Liu; Lisa J. Guerrero; Qiwei Yang; Yufeng Tian; Hele 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 983 KB

Secreted protein, acidic and rich in cysteine (SPARC), is a multifunctional matricellular glycoprotein. In vitro, SPARC has antiangiogenic properties, including the ability to inhibit the proliferation and migration of endothelial cells stimulated by bFGF and VEGF. Previously, we demonstrated that p