✦ LIBER ✦

Laminarin sulfate mimics the effects of heparin on smooth muscle cell proliferation and basic fibroblast growth factor-receptor binding and mitogenic activity

✍ Scribed by Hua-Quan Miao; Rivka Ishai-Michaeli; Tamar Peretz; Israel Vlodavsky

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 1007 KB
Volume: 164
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041640306

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✦ Synopsis

Heparin and heparin-like molecules may function, apart from their effect on hemostasis, as regulators of cell growth and neovascularization. We investigated whether similar effects are exerted by laminarin sulfate, an unrelated polysulfated saccharide isolated from the cell wall of seaweed and composed of chemically 0-sulfated @-(I ,3)-linked glucose residues. Laminarin sulfate exhibits about 30%

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Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of