✦ LIBER ✦

Lactose conformation in aqueous solution from optical rotation

✍ Scribed by Christopher A. Duda; Eugene S. Stevens

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 313 KB
Volume: 206
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(90)80073-c

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✦ Synopsis

A newly developed calculational model for saccharide optical rotation'+ has recently been extended to disaccharides, with applications to cellobiose and maltose'.

Here we apply the model to /?-lactose v-D-galactopyranosyl-( 1+4)-p-D-glucopyranose]. The purpose in doing so is to demonstrate that the model can account for the large difference in optical activity between two disaccharides, lactose and cellobiose, having the same chemical structure in the linkage region, and to develop a picture of the conformational variations of lactose in aqueous solution compatible with calculated potential-energy surfaces,6'7 n.m.r. studies,8,9 and measured optical rotation".

The calculational method, previously described in detaillm5, is based on a coupledoscillator model which requires the solution of the secular equations:

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