Lactobacillus casei cell wall-induced arthritis in rats: Cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and -resistant F344/N rats
✍ Scribed by Thomas J. A. Lehman; Janice B. Allen; Paul H. Plotz; Ronald L. Wilder
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 362 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Previous studies have shown that LEW/N rats are susceptible to and F344/N rats are resistant to the chronic polyarthritis induced by cell walls of group A Streptococcus pyogenes (I ,2). Study of the chronic arthritis which follows the injection of group A S pyogenes cell walls has suggested that the development of chronic arthritis is dependent on deposition and persistence of the bacterial cell wall fragments in synovial tissues and a relative inability of arthritissusceptible rats to neutralize the inflammatory properties of the cell wall fragments (1,2). We recently reported that chronic polyarthritis could also be induced in LEW/N rats by the injection of group B Lactobucillus casei cell walls in aqueous suspension.
To confirm and extend this model we evaluated the pattern of disease in female LEW/N and F344/N rats injected with group B L cusei cell wall fragments.
Female LEW/N rats developed both acute and chronic polyarthritis following injection, but F344/N rats developed only acute arthritis.
To evaluate the role of cell wall deposition and persistence in the pathogenesis of acute and chronic arthritis in these 2 inbred rat strains, group B L casei cell walls internally labeled with I4C L-lysine were prepared and the distribution and persistence of the cell wall fragments measured I , 3, 20, and 66 days ~ From the Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland.