Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, localized in the astrocyte plasma membrane. The regulation of AQP4 is believed to be important for the homeostasis of water in the brain, but the AQP4 regulatory mechanisms are not yet known. In this study, we investigate
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes
β Scribed by Tetsuro Morishima; Mineyoshi Aoyama; Yuko Iida; Naoki Yamamoto; Hiroyuki Hirate; Hajime Arima; Yoshihito Fujita; Hiroshi Sasano; Takako Tsuda; Hirotada Katsuya; Kiyofumi Asai; Kazuya Sobue
- Book ID
- 116775987
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 694 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0168-0102
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## Abstract **Background:** Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, which is localized in the astrocyte plasma membrane. Membrane targeting of AQP4 is essential to perform its function. The mechanism(s) of membrane targeting is not clear in astrocytes. **Resu
Some of the aquaporins (AQPs), a family of water channel proteins, are expressed in astrocytes. The expression of astrocytic AQPs is altered after brain insults, such as ischemia and head trauma. However, little is known about the regulation of AQP expressions. Endothelins (ETs), which are vasoconst