Lactate dehydrogenase isoenzymes in tumours of the nervous system
β Scribed by W. R. Timperley
- Publisher
- Springer-Verlag
- Year
- 1971
- Tongue
- English
- Weight
- 285 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0001-6322
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π SIMILAR VOLUMES
BACKGROUND. Central nervous system (CNS) involvement is common in hematooncologic diseases. The aim of the current study was to determine the diagnostic value of cerebrospinal fluid (CSF) lactate dehydrogenase (LDH) isoenzyme analysis for the diagnosis of CNS involvement in hematooncologic patients.
A newly developed technique was used for the electrophoretic separation of lactate dehydrogenase (LDH) isoenzymes from lyophilized tissue samples in the nanogram range. In this study portions of 10-200 ng from the myocardium and the conducting system of cattle, sheep, pig and man were microdissected
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To evaluate the diagnostic value of lactate dehydrogenase (LD) isoenzymes in cerebrospinal fluid (CSF), 93 consecutive CSF specimens were analyzed. These specimens were from patients of four categories: tumors, infections, hemorrhages, and others. It was found that the isoenzyme patterns overlapped