Lactarane sesquiterpenoids from Lactarius subvellereus and their cytotoxicity

✍ Scribed by Ki Hyun Kim; Hyung Jun Noh; Sang Un Choi; Ki Moon Park; Soon-Ja Seok; Kang Ro Lee

• Book ID: 104004715
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 252 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.07.119

✦ Synopsis

Subvellerolactones B (1), D (2), and E (3), structurally unusual lactarane sesquiterpenoids, were isolated from the fruiting bodies of Lactarius subvellereus together with four known lactarane sesquiterpenes (4-7). The chemical structures and stereochemistries of compounds 1-3 were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments and a convenient Mosher ester procedure. Subvellerolactone B (1) exhibited cytotoxicity against the A549, SK-MEL-2, and HCT-15 cell lines with IC 50 values of 26.5, 18.3, and 14.2 lM, respectively, and subvellerolactones D (2) and E (3) showed cytotoxicity against the A549 and HCT-15 cell lines (IC 50 (2): 25.1 and 17.8 lM, and IC 50 (3): 19.6 and 28.7 lM, respectively).