LaCl3·7H2O/NaI/benzyl alcohol: a novel reagent system for regioselective hydration of glycals: application in the synthesis of 1,6-dideoxynojirimycin

✍ Scribed by Shikha Rani; Aditi Agarwal; Yashwant D Vankar

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 224 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01175-4

✦ Synopsis

Glycals can be readily hydrated using the LaCl 3 •7H 2 O/NaI/PhCH 2 OH reagent system. In one case, having an exo methylene group, such hydration gives an intermediate which is readily converted into 1,6-dideoxynojirimycin, a potential enzyme inhibitor.