𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lack of selective Vβ deletion in peripheral CD4+ T cells of human immunodeficiency virus-infected infants

✍ Scribed by Philippe Bahadoran; Frédéric Rieux-Laucat; Françoise Le Deist; Stéphane Blanche; Alain Fischer; Jean-Pierre de Villartay

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
423 KB
Volume
23
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Lack of selective Vp deletion in peripheral CD4+ T cells of human immunodeficiency virus-infected infants*

To investigate the possibility of superantigen-mediated deletions of T cells expressing particular T cell receptor Vg (TcR Vg) gene segments during human immunodeficiency virus (HIV) infection, TcR Vp usage in CD4+ and CD8+ subsets was analyzed in a cohort of infants maternally infected by HIV and in a group of healthy neonates. We used a semi-quantitative anchored polymerase chain reaction technique together with cytofluorographic analysis with anti-Vg monoclonal antibodies. The representation of the 24 Vp families in CD4+ and CD8+ T cells from normal neonates was very similar to that in adults. Preferential expression of Vp2 in the CD4+ subset was observed in both the neonates and in healthy adults. The representation of the 24 Vp families in peripheral CD4+ T cells from the HIV-infected infants showed no selectivevp deletion, even when the CD4+ subset was globally depleted. Moreover, the main characteristics of the control group (predominance of certainvp families and Vp2 skewing towards the CD4+ subset) were also present in all the HIV-infected infants.

📜 SIMILAR VOLUMES

Functional dichotomy of CD4+ T helper ly
Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection
✍ Mario Clerici; Gene M. Shearer; Charles S. Via; Daniel R. Lucey; Emmanuel Roilid 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 589 KB

## Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection The majority of asymptomatic, human immune deficiency virus seropositive (HIV+) individuals exhibit a defect in CD4+ T helper cell (Th) function that is selective for responses to recall ant

Preferential expression of Vβ6.7 domain
Preferential expression of Vβ6.7 domain on human peripheral CD4+ T cells. Implication for positive selection of T cells in man
✍ Andrea Cossarizza; Melvyn Kahan; Claudio Ortolani; Claudio Franceschi; Marco Lon 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Preferential expression of Vg6.7 domain on human peripheral CD4+ T cells. Implication for positive selection of T cells in man* The peripheral Tcell receptor repertoire is mainly controlled by the processes of positive and negative selection occurring in the thymus. Studies in normal or transge

Influence of HCV genotype and co-infecti
Influence of HCV genotype and co-infection with human immunodeficiency virus on CD4+ and CD8+ T-cell responses to hepatitis C virus
✍ Laura Capa; Vincent Soriano; Javier García-Samaniego; Marina Nuñez; Miriam Romer 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Abstract The role of T‐cells in clearance of hepatitis C virus (HCV) during acute infection is critical. The relevance of the immunological response in the control of HCV replication is less clear in chronic HCV infection. HCV‐specific T‐cell responses were examined in 92 interferon‐naive indivi