We describe a patient with primary Sjogren's syndrome who developed myositis. The results of muscle pathologic analysis before and after treatment with monthly pulses of cyclophosphamide (intravenously), are presented. Late-onset myositis has been described in patients with Sjogren's syndrome (SS)
β¦ LIBER β¦
Lack of response to corticosteroids and pulse cyclophosphamide therapy in Cogan's syndrome
β Scribed by G. Vaiopoulos; P. P. Sfikakis; B. Skoumas; E. Kavouklis; E. Doukas; Ph. Kaklamanis
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 298 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0770-3198
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## Abstract ## Objective Pulse cyclophosphamide is the treatment of choice for severe lupus nephritis. However, not all patients respond to this therapy, and gonadal toxicity is of particular concern. Cyclophosphamide is a prodrug that requires activation by cytochrome P450 (CYP) enzymes. We condu