Lack of response to commercial factor VIII concentrate in hemophilia a
โ Scribed by George M. Rodgers; Marilyn H. Ford
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 113 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
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Hemophilia A is a common X-linked bleeding disorder caused by mutations in the coagulation factor VIII gene. The entire coding and essential sequences of the factor VIII gene were generated by a combination of genomic DNA amplification and long reverse transcription-polymerase chain reaction (long R
Factor Vlll replacement therapy for patients with hemophilia A Is conventionally monitored using a plasma-based factor VII1:C assay (a modified activated partial thromboplastln time [ A P m test). The plasma factor Vlll assay requires the preparation of plasma from cltrated whole blood and measureme