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Lack of protein expression of the simian virus 40 large T antigen in human lymphomas

✍ Scribed by Philip Went; Christian A. Seemayer; Stefano Pileri; Robert Maurer; Alexandar Tzankov; Stephan Dirnhofer

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
77 KB
Volume
80
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Several studies have detected Simian virus 40 (SV40) deoxyribonucleic acid sequences in human tumor tissues, including lymphomas, mainly by the polymerase chain reaction, but these data were not confirmed by subsequent investigations. Regional differences in the distribution of the SV40 and/or technical difficulties have been taken into account to explain these divergent results, but because only a few such studies dealt with the expression of SV40 proteins in tumor tissues, we investigated the expression of the SV40 large T antigen in human lymphomas by immunohistochemistry. Tissue microarrays containing Non‐Hodgkin's‐lymphomas and Hodgkin's‐lymphomas were constructed utilizing archival samples encompassing the years 1974–2001 from Italian, Swiss and Austrian patients. Expression of the SV40 large T antigen was analysed by highly specific and sensitive immunohistochemistry using a mouse monoclonal antibody. Protein expression of the large T antigen was not detected in 655 Non‐Hodgkin's‐lymphomas or in 337 Hodgkin's‐ lymphomas. The results suggest the absence of an association between SV40 large T antigen and human lymphomas. J. Med. Virol. 80:1112–1115, 2008. © 2008 Wiley‐Liss, Inc.

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