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Lack of nephrotoxicity of oral ammine/amine platinum (IV) dicarboxylate complexes in rodents

✍ Scribed by McKeage, MJ; Morgan, SE; Boxall, FE; Murrer, BA; Hard, GC; Harrap, KR

Book ID: 109836856
Publisher: Nature Publishing Group
Year: 1993
Tongue: English
Weight: 979 KB
Volume: 67
Category: Article
ISSN: 0007-0920
DOI: 10.1038/bjc.1993.182

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## Abstract Acquired resistance to tetraplatin [d, I ‐__trans__‐1,2‐diaminocyclohexane tetrachloroplatinum (IV)] has been generated __in vitro__ in the human ovarian carcinoma cell line PXN94; the derived line, PXN94tetR, was 24‐fold resistant to tetraplatin. Intracellular tetraplatin accumulation