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Lack of minocycline efficiency in genetic models of Huntington’s disease

✍ Scribed by Stéphane Mievis; Marc Levivier; David Communi; Gilbert Vassart; Jacques Brotchi; Catherine Ledent; David Blum


Book ID
111642319
Publisher
Humana Press Inc
Year
2007
Tongue
English
Weight
228 KB
Volume
9
Category
Article
ISSN
1535-1084

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## Abstract This study assessed the futility of proceeding with a Phase 3 clinical trial of minocycline as a disease‐modifying treatment for Huntington's disease (HD). One hundred fourteen research participants with HD were randomized, 87 to minocycline (200 mg/d) and 27 to placebo. The change in T