Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents
β Scribed by Lukas Cerveny; Petr Pavek; Jana Malakova; Frantisek Staud; Zdenek Fendrich
- Book ID
- 109108849
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2006
- Tongue
- English
- Weight
- 292 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0013-9580
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Breast cancer resistance protein (BCRP) is an efflux transporter that plays an important role in drug disposition. The goal of this study was to investigate the interactions of azole antifungal agents, ketoconazole, itraconazole, fluconazole, and voriconazole, with BCRP. First, the effect of the azo
## Abstract Breast cancer resistance protein (BCRP/ABCG2) of an ATPβbinding cassette halfβtransporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan. Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cel