Lack of inhibition of glycolytic enzymes by the neurotoxic organophosphorus compounds Mipafox and Methamidofos

Models for the Inhibition of Dithiol-Con

Models for the Inhibition of Dithiol-Containing Enzymes by Organoarsenic Compounds: Synthetic Routes and the Structure of [PhAs(HlipS2)] (HlipS22− = Reduced Lipoic Acid)

✍ Angelika von Döllen; Henry Strasdeit 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 411 KB

## Lipoic acid / S ligands The arsenic(III) dithiolate [PhAs(HlipS 2 )] (1, HlipS 2Ϫ 2 = re-inhibit enzymes that contain lipoic acid as a cofactor. X-ray structure analysis shows that 1 is a 2,4-disubstituted 1,3,2-duced rac-lipoic acid) has been obtained via three different routes: (A) from (PhAs