Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice

Catecholestrogens induce oxidative stres

Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: Protective effect of catechol-O-methyltransferase

✍ Salama A. Salama; Marwa Kamel; Mohamed Awad; Abdel-Hakim Ben Nasser; Ayman Al-He 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 840 KB

## Abstract Prolonged exposure to unopposed estrogens is a major risk factor for the development of endometrial cancer. Oxidative metabolism of estradiol (E~2~) into the catecholestrogens (CEs), 4‐hydroxyestradiol (4‐OHE~2~) and 2‐hydroxyestradiol (2‐OHE~2~), may play an important role in estrogen