✦ LIBER ✦
Lack of glycosidase inhibition by, and isolation from xanthocercis zambesiaca (leguminosae) of, 4-O-(β-D-glucopyranosyl)-fagomine [1,2,5-trideoxy-4-O-(β-D-glucopyranosyl)-1,5-imino-D- arabino-hexitol], a novel glucoside of a polyhydroxylated piperidine alkaloid
✍ Scribed by Stephen V. Evans; Alison R. Hayman; Linda E. Fellows; Tony K.M. Shing; Andrew E.Derome; George W.J. Fleet
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 200 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A COSY spectrum has been used to determine the position of inter-residue linkage in 4-O-(B-D-glucopyranosyl) fagomine (I) an example of a new class of glycosides of polyhydroxylated piperidine alkaloids isolated from seed of the legume Xanthocercis zambesiaca. (Bak.) Dunn. Unlike a number of polyhydroxylated piperidines, neither the glucoside (I~ nor free fagomine [1,2,5-trideoxy-1,5-imino-D-arabinohexitol] (3) showed any inhibitory activity towards glycosidase enzymes from a va~f sources.