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Lack of glutathione peroxidase-1 exacerbates Aβ-mediated neurotoxicity in cortical neurons

✍ Scribed by P. J. Crack; K. Cimdins; U. Ali; P. J. Hertzog; R. C. Iannello

Book ID
106206883
Publisher
Springer
Year
2005
Tongue
English
Weight
190 KB
Volume
113
Category
Article
ISSN
1435-1463

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in