Lack of Expression of HLA Antigens on Choriocarcinoma Cell Lines
โ Scribed by Elizabeth A. Jones; Walter F. Bodmer
- Book ID
- 115093115
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 445 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0001-2815
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
HLA class I molecules present antigenic peptides to cytotoxic T lymphocytes and thus play an important role in immune surveillance of cells infected with virus or altered by malignant transformation. Immunochemical studies have demonstrated a marked deficiency or lack of expression of class I molecu
Jeg-3 choriocarcinoma cells express class-I MHC HLA-G and low levels of a novel HLA-C product. The functional significance of such novel MHC class-I expression in regard of the cellular immune response has been investigated. Jeg-3 cells are NK-insensitive, but susceptible to LAK cytotoxicity, some o