Lack of evidence of circulating retroviral antibodies in patients with classic Hodgkin's disease
β Scribed by T. L. Chorba; V. S. Kalyanaraman; M. J. Lacher; R. S. Schulof
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 336 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## BACKGROUND To explore the potential role of infiltrating benign B cells in classic Hodgkin disease (HD) lesions in supporting the survival of malignant Hodgkin and ReedβSternberg (H/RS) cells, the authors initiated a pilot study of rituximab. Rituximab is used to primarily deplete n
## Epstein-Barr virus (EBV) is detected in Hodgkin and Reed-Sternberg (HRS) cells in up to 50% of patients with Hodgkin's disease (HD). HD patients have been reported to express high serum titers against EBV antigens, even prior to the diagnosis of HD. Patients with high serum titers have a poorer