✦ LIBER ✦
Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme a formation in male and female rats
✍ Scribed by Kuslikis, Benedict I. ;Vanden Heuvel, John P. ;Peterson, Richard E.
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 498 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0887-2082
No coin nor oath required. For personal study only.
✦ Synopsis
Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxi-soma1 proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a CoA conjugate of clofibric acid, no corresponding CoA derivative could be found for either PFDA or PFOA.