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Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety

✍ Scribed by Ana M. Basso; Natalie A. Bratcher; Kelly B. Gallagher; Marlon D. Cowart; Chen Zhao; Minghua Sun; Timothy A. Esbenshade; Michael E. Brune; Gerard B. Fox; Martin Schmidt; Christine A. Collins; Andrew J. Souers; Rajesh Iyengar; Anil Vasudevan; Philip R. Kym; Arthur A. Hancock; Lynne E. Rueter

Book ID
113586185
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
290 KB
Volume
540
Category
Article
ISSN
0014-2999

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Melanin-concentrating hormone receptor 1
Melanin-concentrating hormone receptor 1 antagonists for the treatment of depression and anxiety
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## Abstract Melanin‐concentrating hormone (MCH) is a cyclic, 19‐amino‐acid neuropeptide produced in the lateral hypothalamus. MCH is implicated in a number of physiological processes including feeding behavior, energy balance, reproductive function, memory, sleep‐wake regulation, and emotional stat