✦ LIBER ✦

Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis

✍ Scribed by Yang-Te Tsai; Fa-Yauh Lee; Han-Chieh Lin; Ting-Tsung Chang; Chii-Shyan Lay; Sun-Sang Wang; Chi-Woon Kong; Shou-Dong Lee; Kwang-Juei Lo

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 543 KB
Volume: 10
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840100305

No coin nor oath required. For personal study only.

✦ Synopsis

We conducted a randomized controlled hemodynamic study to evaluate the effect of placebo and 20 mg isosorbide-5-mononitrate, a long-acting organic nitrate, in 19 patients with HBsAg-positive cirrhosis by the simultaneous measurement of portal venous pressure and wedged hepatic venous pressure. Baseline values for the two groups were similar. One hour after oral administration of 20 mg isosorbide-5-mononitrate in 10 patients, mean arterial pressure, mean pulmonary arterial pressure and pulmonary capillary wedge pressure significantly decreased from 92 k 13 (mean f S.D.) to 82

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