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Lack of effect of the specific cholecystokinin receptor antagonist loxiglumide on cholecystokinin clearance from plasma in man.

โœ Scribed by MC Jebbink; JB Jansen; AA Masclee; CB Lamers


Book ID
117944977
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
537 KB
Volume
29
Category
Article
ISSN
0306-5251

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Cholecystokinin was previously proposed to play an important role in the regulation of postprandial insulin secretion either indirectly, by inhibiting gastric meal emptying, or directly, by acting as an incretin promoting the release of insulin. The aim of this investigation was therefore to clarify

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Cholecystokinin (CCK)-receptor antagonists have been reported to inhibit the effects of the hormone on the gastrointestinal tract. Their effect on plasma CCK levels in man has not been described. The present study in 5 normal subjects demonstrated that i.v. infusion of the potent, specific CCK-recep