Lack of effect of moderate hepatic impairment on the pharmacokinetics of oral oseltamivir and its metabolite oseltamivir carboxylate
โ Scribed by Paul Snell; Nisha Dave; Katie Wilson; Lucy Rowell; Angelica Weil; Lawrence Galitz; Richard Robson
- Book ID
- 108640331
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 140 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0306-5251
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We previously showed that oseltamivir, a prodrug of the influenza virus neuraminidase inhibitor Ro 64-0802, is a substrate of proton-coupled oligopeptide transporter (PEPT1), and its intestinal absorption in rats is markedly inhibited by administration with milk. To investigate the importance of PEP
Azimilide dihydrochloride (75-125 mg/day) is currently being developed for use in prolonging the time to recurrence of atrial fibrillation/flutter and for reducing the frequency of shocks in patients with an implantable cardioverting defibrillator. This study investigated the influence of mild and m