Lack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat
β Scribed by L. Reyneke; R. Allin; V. A. Russell; J. J. F. Taljaard
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 504 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0364-3190
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π SIMILAR VOLUMES
Recent studies indicate that an increase in serotonergic (5-HT) activity in the nucleus accumbens (NAc) produces an increase in dopamine (DA) release, providing a possible mechanism for the involvement of DA in the therapeutic action of selective serotonin reuptake inhibitor (SSRI) antidepressants.
Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the β₯-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependenceproducing properties, as