Lack of Effect of Cholesterol Esterase Inhibitor CVT-1 on Cholesterol Absorption and LDL cholesterol in Humans
β Scribed by Matthew S. Bosner; Andrew A. Wolff; Richard E. Ostlund
- Book ID
- 110255591
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 93 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0920-3206
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The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but
2 dimethylpropyl) phenyl)ethyl)phenyl)urea) is an inhibitor of human microsomal AcylCoA: Cholesterol acyltransferase (ACAT) with an ICs0 of 10.2 rig' m1-1 (23 nM). It is poorly absorbed but 5 mg. kg-1-daycompletely abolishes the rise in plasma cholesterol in cholesterol-fed rats. In this study, tw