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Lack of DNA single-strand breaks in rat liver cells exposed to 4-acetylaminofluorene, in vivo and in vitro

✍ Scribed by C. Nizard; F. Decloître


Book ID
113255437
Publisher
Elsevier Science
Year
1990
Weight
404 KB
Volume
244
Category
Article
ISSN
0165-7992

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Induction of single-strand breaks and in
✍ Ruthsatz, M. ;Neumann, H.-G. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB

2-Acetylaminofluorene (AAF) or trans-4-acetylaminostilbene (AAS) was orally or intraperitoneally administered to female Wistar rats. DNA from liver cells was analyzed for single-strand breaks by the alkaline elution assay. Only borderline effects were observed with doses (100 pmol/kg) used in animal